Osteoprotegrin Knockout Mice Demonstrate Abnormal Remodeling of the Otic Capsule and Progressive Hearing Loss
نویسندگان
چکیده
منابع مشابه
Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28.
Congenital and progressive hearing impairment is a common distressing disease. The progressive dominant hearing loss DFNA28 in human is associated with a frameshift mutation of Grainyhead-like 2 (GRHL2) but its etiology and mechanism remain unknown. Here we report a zebrafish grhl2b(T086) mutant line in which grhl2b expression is interrupted by an insertion of a Tol2 transposon element. The mut...
متن کاملAge-Related Hearing Loss in Mn-SOD Heterozygous Knockout Mice
Age-related hearing loss (AHL) reduces the quality of life for many elderly individuals. Manganese superoxide dismutase (Mn-SOD), one of the antioxidant enzymes acting within the mitochondria, plays a crucial role in scavenging reactive oxygen species (ROS). To determine whether reduction in Mn-SOD accelerates AHL, we evaluated auditory function in Mn-SOD heterozygous knockout (HET) mice and th...
متن کاملProgressive visual and hearing loss as looming manifestations of spinal meningeal melanocytoma
Abstract Meningeal melanocytoma is a rare tumor of nervous system, which originates from leptomeningeal melanocytes. The locations of melanocytoma in the nervous system are most frequently in the posterior fossa or along the spinal cord, and usually appear as an extra-axial mass. The manifestations of tumor are most often due to its compressing effect on adjacent nervous structures that c...
متن کاملTherapeutic effect of electroacupuncture in a p75 knockout mouse model of progressive hearing loss.
Neurotrophin receptor p75 (p75) knockout mice (p75 (−/−) mice) provide a good animal model of progressive-onset hearing loss. Cell loss of the spiral ganglion neurons (SGNs) and hair cell degeneration at the basal turn of the cochlea are seen in p75(−/−) mice from 3 months of age. Furthermore, from 3 to 6 months of age, the hearing thresholds of p75(−/−) mice are gradually raised; and after 6 m...
متن کاملProgressive cone dystrophy and sensorineural hearing loss.
A 39-year old man presented 13 years ago with a history of progressive loss of vision and photophobia. A full ophthalmological and ENT work-up during several years of follow-up, including psychophysical as well as electrophysiological tests, revealed a progressive cone dystrophy in combination with sensorineural hearing loss. His younger sister presented with very similar features and underwent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Laryngoscope
سال: 2006
ISSN: 0023-852X
DOI: 10.1097/01.mlg.0000191466.09210.9a